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Amiline (Amitriptyline)

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Amiline is an antidepressant medication that is sometimes prescribed off-label to manage chronic back pain. It is one of the drugs in a class of drugs known as tricyclic antidepressants. Amiline is not a narcotic (opioid) drug, and there is not usually an addiction risk with the medication.

Other names for this medication:
Amiclozor, Amicure, Amitriptyline, Amitrol, Amitryptyline, Amity, Amiwel, Amizep, Amtran, Anitryp, Aptric, Arpidox, Chlotrip, Cotrip, Endep, Estiline, Gentrip, Latilin, Libotryp, Lodep, Maxitrip, Mitrip, Mitryp, Nextrip, Ristryl, Sarotena, Triplent, Tryline, Typlin, Typteez, Zodep

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Also known as: Amitriptyline


Amiline (amitriptyline) is a tricyclic antidepressant with sedative effects. Amitriptyline affects certain chemical messengers (neurotransmitters) that communicate between brain cells and help regulate mood.

Amiline is a prescription medicine used to treat symptoms of depression.


Usual Adult Dose for Depression:

OUTPATIENTS: -Initial dose: 75 mg orally per day in divided doses; this may be increased to 150 mg/day (if needed) -Maintenance dose: 40 to 100 mg orally per day -Maximum dose: 150 mg/day Alternate outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime; this may be increased by 25 or 50 mg as needed at bedtime to a total of 150 mg/day INPATIENTS: -Initial dose: 100 mg orally per day -Maintenance dose: 40 to 100 mg orally as a single dose at bedtime -Maximum dose: 300 mg/day Comments: -Dose increases should preferably be made in the late afternoon or at bedtime due to the sedative effect. -The full therapeutic effect may take as long as 30 days to develop. -Maintenance doses should be reduced to the lowest amount that will maintain relief of symptoms when satisfactory improvement has been obtained. -Maintenance therapy should be continued for 3 months or longer to lessen the possibility of relapse. Use: Relief of symptoms of depression

Usual Geriatric Dose for Depression:

10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Elderly patients should be monitored carefully and serum levels obtained as clinically appropriate. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Usual Pediatric Dose for Depression:

12 years or older: 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. -Dose adjustments should be made according to clinical response. Use: Relief of symptoms of depression

Detailed Amiline dosage information


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amitriptyline can be fatal.

Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma.


Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amiline are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


You should not use Amiline if you are allergic to amitriptyline, or:

if you have recently had a heart attack.

Do not use Amiline if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Tell your doctor if you have used an "SSRI" antidepressant in the past 5 weeks, such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone.

To make sure Amiline is safe for you, tell your doctor if you have ever had:

bipolar disorder (manic-depression) or schizophrenia; mental illness or psychosis; liver disease; heart disease; a heart attack, stroke, or seizures; diabetes (amitriptyline may raise or lower blood sugar); glaucoma; or problems with urination.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

Tell your doctor if you are pregnant or breastfeeding.

Amiline is not approved for use by anyone younger than 12 years old.

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Lidocaine, but not phenytoin, caused a time-dependent block of tail currents evoked by membrane depolarizations lasting 10-1000 ms. Our cross-linking experiments with iodinated TGF-beta showed that in osteoblast-enriched bone cell cultures, both TGF-beta 3 and TGF-beta 1 associated with the same three cell surface binding sites. Single-level pedicle subtraction osteotomy has satisfactory effectiveness for the correction of kyphosis caused by ankylosing spondylitis. The fixation of C3b to pneumococcal cell wall polymers as a result of activation of the alternative complement pathway. Integration of liver models into organs-on-a-chip devices, permitting crosstalk between tissue types, is actively being pursued to obtain a systems-level understanding of drug effects. On the contrary, other species with limited frequency ranges showed almost linear stress-strain curves because of the higher elastin and lower collagen contents. To assess trends in the use of antidepressants among young suicides after the warning that these drugs might increase the risk of suicide. We studied a French cohort of 165 ALS/FTLD patients, without finding any variant. Analysis and correction of gradient nonlinearity bias in apparent diffusion coefficient measurements. The single nucleotide polymorphism (SNP), rs1333049 on chromosome 9p21.3 has been strongly associated with CAD and myocardial infarction.

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The density--viscosity--temperature relationship of infusion solutions. Microscopic examination of the excised mass confirmed the diagnosis of posterior mediastinal angiomyxolipoma. To overcome this problem, we optimized an approach for whole mount labeling of cilia, leading to improved visualization of their morphology and the distribution of signaling proteins. for PPIs descending from a common ancestral PPI, should be a successful strategy for PPI validation. The aim of this study was to analyze the indications and complications of surgery as well as endocrine results. By this packaging, US3 might be brought close to the gB CT tail, leading to phosphorylation and triggering fusion between the virion envelope and the outer NM. To suggest an alternative model of care that involves general practitioners with a special interest in CHF liaising with, and being up-skilled by, specialists within community based, multidisciplinary general practice settings. While the etiology of this lesion may not always be the same, the major gross abnormalities are usually constant. Correct analysis of libraries prior to sequencing has proven to be a vital step for specific assumption and to some extent for a more parallel testing.

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Patch-clamp electrophysiology, Western blot, and ELISA were performed to examine the effects of NE. Twelve hours after disulphiram administration the suppression of the open-field behavior and reproduction of the conditioned avoidance response as well as the depletion of noradrenaline fluorescence in the investigated structures were detected. This paper presents a review of noninvasive, nonpharmacologic behavioral support techniques with discussion regarding their application to persons with special care needs. In this framework, state estimation uses an internal model of body and sensor dynamics to process sensory information and determine body orientation. However, additional research is needed in designing a neuroimaging stress task that will yield a significant cortisol stress response consistently, across populations and laboratories. The calculated reaction barrier of the first excited state of C456:3H2O with 200 water molecules is found to be -0.23 kcal/mol without zero-point energy (-5.07 kcal/mol with zero point energy, i.e., the activation energy). Robust representation of stable object values in the oculomotor Basal Ganglia.

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MR- and CFD-measurements show influences of the stenosis shape, especially the diameter. Minihepcidins are small peptides that mimic biological activity of the iron-regulatory hormone hepcidin. Update in salivary gland cytopathology: Recent molecular advances and diagnostic applications. A randomized, placebo-controlled study of the effects of naproxen, aspirin, celecoxib or clopidogrel on gastroduodenal mucosal healing. Estrogen receptor alpha phosphorylation and its functional impact in human breast cancer. Family reactions to surgical correction for kyphoscoliosis in spina bifida children: a preliminary report.

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